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Need Help. Confused: Uvs and zbrush texturing.

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Need Help. Confused: Uvs and zbrush texturing.

Hi guys. I'm having a little dilemma. I don't really have anyone to guide me through this or I can't find a real definite answer through tutorials and such. I don't have much experience with texturing but from what I already know I don't want to move forward until I'm positive. 

If I wanted to use polypaint and add some alphas onto my model in zbrush will my uvs that I did in Uv layout be affected dramatically? Will I've to retouch the uvs or am I safer adding everything i need before i do the uvs?

I'm aware if I wanted to sculpt details on my model its best to do that before
placing uvs but not sure about painting or using alphas will do any significant 
damage?

Any advice or suggestions would greatly be appreciated.