In this animated world, villainy is a corporate venture. Master criminals live among the average citizens, clearly out in the open. The gothic mansion of baddie Gru sticks out in the same row of suburban family homes. To fund criminal ventures, the villains apply for loans from the Bank of Evil (formerly known as Lehman Brothers).
Gru (Steve Carell, GET SMART) wants to be the top criminal mastermind, but he has competition in the newcomer Vector (Jason Segal, I LOVE YOU, MAN), who just stole the Great Pyramid, which he has stowed in his backyard, painting it blue so that it blends in with the skyline. Gru; along with his mad scientist cohort Dr. Nefario (Russell Brand, GET HIM TO THE GREEK) and hundreds of his minions, yellow pill-shaped sidekicks who get giddy over troublemaking; go to the Bank of Evil to get the funding for his biggest caper yet — steal the Moon. But before he can get to the Moon, he has to build a rocketship and steal a newly created Chinese shrink ray. The key to getting the ray — three orphans named Margo (Miranda Cosgrove, TV's ICARLY), Edith (Dana Gaier) and Agnes (Elsie Fisher).