Setting up for Software
The 21UX will work with any software as a stylus/mouse, but it will more importantly utilize any program that has pen/pressure sensitivity built into it. You will see from the image above I have settings for Painter Sketch Photoshop & ZBrush assigned in my Wacom utility.

Express Keys
16 Express keys offer shortcuts to common tasks; I map all my keyboard shortcuts to these keys.

Dial
By pressing the dial it cycles through x 4 touchstrip functions. By default, these are auto scroll/zoom, cycle layers, brush size and canvas rotation, but, again, I customize these based on which software I am using.

TouchStrips
These are an interesting solution for giving adjustable scaling solutions for certain functions, with the touch of your finger. You slide your finger up and down on the strips and it will provide a scaling function between two ends of a purpose, like making brush size bigger or smaller, opacity 0-100%; however, on the 21UX these are now rear mounted, which prove to be more ergonomically suited to your hand, and also help avoid you brushing them by mistake.

Conclusion
I have been a fan and user of Wacom tablets for years and the upgrade to a Cintiq in the past was extremely tempting, but still for many considered a luxury. But now, after creating on the new Cintiq and experiencing the speed, control and sensitivity it provides, you too may realize that it is an absolutely invaluable investment, and you simply can't go back to working any other way. 

Andrew Cawrse is founder and director of Anatomy Tools.com, and has had a distinguished background in design and movie visual effects, with more than nine years at Industrial Light & Magic as a model supervisor and digital concept sculptor. His effects work has been featured on Avatar, The Spiderwick Chronicles,Van Helsing, Dreamcatcher, Star Wars Episode I & II, Mission to Mars and Galaxy Quest. He was also a technical consultant on Pirates of the Caribbean II.